• Junggeon Park, Jin Jeon, Byongyeon Kim

Electrically Conductive Hydrogel Nerve Guidance Conduits for Peripheral Nerve Regeneration

2020년 9월 22일 업데이트됨

Academic Journal

Advanced Functional Materials

Early View, 12 August 2020

Impact Factor : 16.836


Author

Junggeon Park, Jin Jeon, Byongyeon Kim, Min Suk Lee, Sihyeon Park, Juhan Lim, Jongdarm Yi, Hwangjae Lee, Hee Seok Yang,* and Jae Young Lee*


Abstract

Peripheral nerve injuries are serious conditions, and surgical treatment has critical limitations. Therefore, nerve guidance conduits (NGCs) are proposed as an alternative. In this study, multifunctional NGCs are fabricated for the regeneration of injured peripheral nerves. Graphene oxide (GO) and gelatin-methacrylate (GelMA) are polymerized and chemically reduced to form reduced (GO/GelMA) (r(GO/GelMA)). The prepared materials present good electrical conductivity, flexibility, mechanical stability, and permeability, which are suitable for use as NGCs. In vitro studies show 2.1- and 1.4-fold promotion of neuritogenesis of PC12 neuronal cells on r(GO/GelMA) compared to GelMA and unreduced GO/GelMA, respectively. Animal studies using a rat sciatic nerve injury model with a 10 mm gap between the proximal and distal regions of the defect reveal that r(GO/GelMA) NGCs significantly enhance peripheral nerve regeneration, indicated by improved muscle weight increase, electro-conduction velocity, and sciatic nerve function index. Specifically, r(GO/GelMA) NGCs are utilized to potentiate regrowth with myelination in rat sciatic nerves followed by histological, immunohistological, and morphometrical analyses. This study successfully shows the feasibility of electrically conductive hydrogel NGCs as functional conduits for improved nerve regeneration in a preclinical study, where these NGCs can not only mimic nerve tissues but also strongly promote nerve regeneration.

Keywords conductive hydrogels, gelatin, graphene, nerve guidance conduits, peripheral neural regeneration

조회 33회댓글 0개

최근 게시물

전체 보기

 SCATE│Stem Cell And Tissue Engineering

 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam, 31116, Korea

 Professor Email : hsyang@dankook.ac.kr

 Website Manager : syc00319@gmail.com

 Tell : +82-41-550-1177

  • Facebook Clean
  • Twitter Clean
  • White Google+ Icon
  • LinkedIn Clean