전진 대학원생, BRIC '한빛사'에 오르다
단국대학교 나노바이오의과학과 줄기세포 및 조직공학연구실(Stem Cell And Tissue Engineering; SCATE lab) 소속 석박사통합과정 전진 학생이 BRIC(생물학연구정보센터) 한빛사(한국을 빛낸 사람들)에 게재되었다.
Electrically Conductive Hydrogel Nerve Guidance Conduits for Peripheral Nerve Regeneration
Peripheral nerve injuries are serious conditions, and surgical treatment has critical limitations. Therefore, nerve guidance conduits (NGCs) are proposed as an alternative. In this study, multifunctional NGCs are fabricated for the regeneration of injured peripheral nerves. Graphene oxide (GO) and gelatin‐methacrylate (GelMA) are polymerized and chemically reduced to form reduced (GO/GelMA) (r(GO/GelMA)). The prepared materials present good electrical conductivity, flexibility, mechanical stability, and permeability, which are suitable for use as NGCs. In vitro studies show 2.1‐ and 1.4‐fold promotion of neuritogenesis of PC12 neuronal cells on r(GO/GelMA) compared to GelMA and unreduced GO/GelMA, respectively. Animal studies using a rat sciatic nerve injury model with a 10 mm gap between the proximal and distal regions of the defect reveal that r(GO/GelMA) NGCs significantly enhance peripheral nerve regeneration, indicated by improved muscle weight increase, electro‐conduction velocity, and sciatic nerve function index. Specifically, r(GO/GelMA) NGCs are utilized to potentiate regrowth with myelination in rat sciatic nerves followed by histological, immunohistological, and morphometrical analyses. This study successfully shows the feasibility of electrically conductive hydrogel NGCs as functional conduits for improved nerve regeneration in a preclinical study, where these NGCs can not only mimic nerve tissues but also strongly promote nerve regeneration.
conductive hydrogels, gelatin, graphene, nerve guidance conduits, peripheral neural regeneration
논문정보 - 형식: Research article
- 게재일: 2020년 08월 (BRIC 등록일 2020-08-26)
- 연구진: 국내연구진
- 분야: Biochemistry, Biotechnology, Neuroscience
Adv. Funct. Mater., First published: 12 August 2020 |
2020. 08. 26